|
2023
|
1. Weihai Liu, Yun Wang, Luiz HM Bozi, Patrick Fischer, Mark P Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, Evanna L Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien Tran, Sally Winther, Stephen M Hinshaw, Jingnan Shen, Hyuk-Soo Seo, Kijun Song, Andrew Z Xu, Luke Sebastian, Jean Zhao, Sirano Dhe-Paganon, Jianwei Che, Steven P Gygi, Haribabu Arthanari, Edward T Chouchani.
Lactate regulates cell cycle by remodeling the anaphase promoting complex. Nature 2. Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk-Soo Seo, Ekaterina V Vinogradova, Tomer M Yaron, Evanna L Mills, Haopeng Xiao, Kristine Senkane, Emily M Huntsman, Jared L Johnson, Jianwei Che, Lewis C Cantley, Benjamin F Cravatt, Sirano Dhe-Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S Gray, Edward T Chouchani. Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor Nature Chemical Biology 3. Pascal Devant, Elvira Boršić, Elsy M Ngwa, Haopeng Xiao, Edward T Chouchani, Jay R Thiagarajah, Iva Hafner-Bratkovič, Charles L Evavold, Jonathan C Kagan. Gasdermin D pore-forming activity is redox-sensitive. Cell Reports 4. Melanie J Mittenbühler, Mark P Jedrychowski, Jonathan G Van Vranken, Hans-Georg Sprenger, Sarah Wilensky, Phillip A Dumesic, Yizhi Sun, Andrea Tartaglia, Dina Bogoslavski, A Mu, Haopeng Xiao, Katherine A Blackmore, Anita Reddy, Steven P Gygi, Edward T Chouchani, Bruce M Spiegelman. Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. Cell Metabolism 5. Juliane Cruz Campos, Luiz Henrique Marchesi Bozi, Barbara Krum, Luiz Roberto Grassmann Bechara, Nikolas Dresch Ferreira, Gabriel Santos Arini, Rudá Prestes Albuquerque, Annika Traa, Takafumi Ogawa, Alexander M van der Bliek, Afshin Beheshti, Edward T Chouchani, Jeremy M Van Raamsdonk, T Keith Blackwell, Julio Cesar Batista Ferreira. Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics. PNAS |
|
2022
|
1. Haopeng Xiao, Luiz HM Bozi, Yizhi Sun, Christopher L Riley, Vivek M Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L Mills, Margo P Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M Cypess, Andrew P White, Yuchen He, Rebecca Deng, Heiko Schöder, Joao A Paulo, Mark P Jedrychowski, Alexander S Banks, Yu-Hua Tseng, Paul Cohen, Linus T Tsai, Evan D Rosen, Samuel Klein, Maria Chondronikola, Fiona E McAllister, Nick Van Bruggen, Edward L Huttlin, Bruce M Spiegelman, Gary A Churchill, Steven P Gygi, Edward T Chouchani.
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell 2. Ambre M Bertholet, Andrew M Natale, Paola Bisignano, Junji Suzuki, Andriy Fedorenko, James Hamilton, Tatiana Brustovetsky, Lawrence Kazak, Ryan Garrity, Edward T Chouchani, Nickolay Brustovetsky, Michael Grabe, Yuriy Kirichok. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature 3. Michael P Murphy, Edward T Chouchani. Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel. Nature Chemical Biology 4. Lydia Dyck, Hannah Prendeville, Mathilde Raverdeau, Mieszko M Wilk, Roisin M Loftus, Aaron Douglas, Janet McCormack, Bruce Moran, Michael Wilkinson, Evanna L Mills, Michael Doughty, Aurelie Fabre, Helen Heneghan, Carel LeRoux, Andrew Hogan, Edward T Chouchani, Donal O’Shea, Donal Brennan, Lydia Lynch. Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Journal of Experimental Medicine |
|
2021
|
1. Evanna L Mills, Cathal Harmon, Mark P Jedrychowski, Haopeng Xiao, Anja V Gruszczyk, Gary A Bradshaw, Nhien Tran, Ryan Garrity, Dina Laznik-Bogoslavski, John Szpyt, Hannah Prendeville, Lydia Lynch, Michael P Murphy, Steven P Gygi, Bruce M Spiegelman, Edward T Chouchani.
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Cell Metabolism 2. Accalia Fu, Lara van Rooyen, Lindsay Evans, Nina Armstrong, Daina Avizonis, Tatsuya Kin, Gregory H Bird, Anita Reddy, Edward T Chouchani, Marc Liesa-Roig, Loren D Walensky, AM James Shapiro, Nika N Danial. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Reports 3. Omer Keinan, Joseph M Valentine, Haopeng Xiao, Sushil K Mahata, Shannon M Reilly, Mohammad Abu-Odeh, Julia H Deluca, Benyamin Dadpey, Leslie Cho, Austin Pan, Ruth T Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M Evans, Aldons J Lusis, Markku Laakso, Edward T Chouchani, Mikael Ryde’n, Alan R Saltiel. Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature 4. Evanna L Mills, Cathal Harmon, Mark P Jedrychowski, Haopeng Xiao, Ryan Garrity, Nhien V Tran, Gary A Bradshaw, Accalia Fu, John Szpyt, Anita Reddy, Hannah Prendeville, Nika N Danial, Steven P Gygi, Lydia Lynch, Edward T Chouchani. UCP1 governs liver extracellular succinate and inflammatory pathogenesis. Nature Metabolism 5. Yizhi Sun, Janane F Rahbani, Mark P Jedrychowski, Christopher L Riley, Sara Vidoni, Dina Bogoslavski, Bo Hu, Phillip A Dumesic, Xing Zeng, Alex B Wang, Nelson H Knudsen, Caroline R Kim, Anthony Marasciullo, José L Millán, Edward T Chouchani, Lawrence Kazak, Bruce M Spiegelman. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature 6. Wenchao Lu, Milka Kostic, Tinghu Zhang, Jianwei Che, Matthew P Patricelli, Lyn H Jones, Edward T Chouchani, Nathanael S Gray. Fragment-based covalent ligand discovery. RSC Chemical Biology 7. Shuai Yan, Manju Kumari, Haopeng Xiao, Christopher Jacobs, Shihab Kochumon, Mark Jedrychowski, Edward T Chouchani, Rasheed Ahmad, Evan D Rosen. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. Journal of Clinical Investigation 8. Evanna L Mills, Haopeng Xiao, Edward T Chouchani. AIDA and UCP1 snuggle up to prevent hypothermia. Nature Cell Biology 9. Damien Lagarde, Yannick Jeanson, Corinne Barreau, Cedric Moro, Lindsay Peyriga, Edern Cahoreau, Christophe Guissard, Emmanuelle Arnaud, Anne Galinier, Anne-Karine Bouzier-Sore, Luc Pellerin, Edward T Chouchani, Luc Penicaud, Isabelle Ader, Jean-Charles Portais, Louis Casteilla, Audrey Carrière. Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes. Journal of Biological Chemistry |
|
2020
|
1. Anita Reddy, Luiz HM Bozi, Omar K Yaghi, Evanna L Mills, Haopeng Xiao, Hilary E Nicholson, Margherita Paschini, Joao A Paulo, Ryan Garrity, Dina Laznik-Bogoslavski, Julio CB Ferreira, Christian S Carl, Kim A Sjøberg, Jørgen FP Wojtaszewski, Jacob F Jeppesen, Bente Kiens, Steven P Gygi, Erik A Richter, Diane Mathis, Edward T Chouchani*.
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise. Cell 2. Mark P Jedrychoswki* , Gina Z Lu , John Szypt , Marco Mariotti , Ryan Garrity , Joao A Paulo , Devin K Schweppe , Dina Laznik-Bogoslavski , Lawrence Kazak , Michael P Murphy , Vadim N Gladyshev , Steven P Gygi , Edward T Chouchani* , Bruce M Spiegelman*. Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis and obesity. PNAS 3. Qing Yu , Haopeng Xiao , Mark P Jedrychowski , Devin K Schweppe , Jose Navarrete-Perea , Jeffrey Knott , John Rogers , Edward T Chouchani , Steven P Gygi. Sample multiplexing for targeted pathway proteomics: application to aging mice. PNAS 4. Haopeng Xiao, Mark P Jedrychowski, Devin K Schweppe, Edward L Huttlin, Qing Yu, David E Heppner, Jiaming Li, Jiani Long, Evanna L Mills, John Szpyt, Zhixiang He, Guangyan Du, Ryan Garrity, Anita Reddy, Laura Pontano Vaites, Joao A Paulo, Tinghu Zhang, Nathanael S Gray, Steven P Gygi, Edward T Chouchani*. A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell 5. Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M Metelo, Michelle L Kelley, Surendra Punganuru, Kyung Bo Kim, Benjamin Olenchock, Eugene Rhee, Andrew M Intlekofer, Edward T Chouchani, Jing-Ruey Joanna Yeh. Nitrogen trapping as a therapeutic strategy in tumors with mitochondrial dysfunction. Cancer Research |
|
2019
|
1. P. Kent Langston, Aya Nambu, Jonathan Jung, Munehiko Shibata, H. Ibrahim Aksoylar, Jiahui Lei, Peining Xu, Mary T. Doan, Helen Jiang, Michael R. MacArthur, Xia Gao, Yong Kong, Edward T. Chouchani, Jason W. Locasale, Nathaniel W. Synder, Tiffany Horng.
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature Immunology 2. Ambre M Bertholet, Edward T. Chouchani, Lawrence Kazak, Alessia Angelin, Andriy Fedorenko, Jonathan Z Long, Sara Vidoni, Ryan Garrity, Joonseok Cho, Naohiro Terada, Douglas C Wallace, Bruce M Spiegelman, Yuriy Kirichok. H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature 3. Lawrence Kazak, Janane F Rahbani, Bozena Samborska, Gina Z Lu, Mark P Jedrychowski, Mathieu Lajoie, Song Zhang, LeeAnn Ramsay, Florence Y Dou, Danielle Tenen, Edward T Chouchani , Petras Dzeja, Ian R Watson, Linus Tsai, Evan D Rosen, Bruce M Spiegelman. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nature Metabolism 4. Edward T Chouchani* & Shingo Kajimura*. Metabolic adaptation and maladaptation in adipose tissue. Nature Metabolism |
|
2018
|
1. Edward T Chouchani*, Lawrence Kazak* & Bruce M Spiegelman*.
New Advances in Adaptive Thermogenesis: UCP1 and Beyond. Cell Metabolism 2. Evanna L Mills, Kerry A Pierce, Mark P Jedrychowski, Ryan Garrity, Sally Winther, Sara Vidoni, Takeshi Yoneshiro, Jessica B Spinelli, Gina Z Lu, Lawrence Kazak, Alexander S Banks, Marcia C Haigis, Shingo Kajimura, Michael P Murphy, Steven P Gygi, Clary B Clish, Edward T. Chouchani*. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature 3. Joao A Paulo, Mark P Jedrychowski, Edward T Chouchani, Lawrence Kazak & Steven P Gygi. Multiplexed Isobaric Tag-Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy. Proteomics 4. Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C Runtsch, Martin S King, Joanna F McGouran, Roman Fischer, Benedikt M Kessler, Anne F McGettrick, Mark M.Hughes, Richard G Carroll, Lee M Booty, Elena V Knatko, Paul J Meakin, Michael L J Ashford, Louise K Modis, Gino Brunori, Daniel C Sévin, Padraic G Fallon, Stuart T Caldwell, Edmund R. S. Kunji, Edward T Chouchani, Christian Frezza, Albena T Dinkova-Kostova, Richard C Hartley, Michael P Murphy, Luke A. O’Neill. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 Nature |
|
2017
|
1. Edward T Chouchani*, Lawrence Kazak*, Bruce M Spiegelman*.
Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms. Journal of Biological Chemistry 2. Lawrence Kazak, Edward T Chouchani, Gina Z Lu, Mark P Jedrychowski, Curtis J Bare, Amir I Mina, Manju Kumari, Song Zhang, Ivan Vuckovic, Dina Laznik-Bogoslavski, Petras Dzeja, Alexander S Banks, Evan D. Rosen, Bruce M Spiegelman. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metabolism 3. Edward T Chouchani*, Andrew M James*, Carmen Methner, Victoria R Pell, Tracy A Prime, Brian K Erikson, Marleen Forkink, Gigi Y Lau, Thomas P Bright, Katja E Menger, Ian M Fearnley, Thomas Krieg, Michael P Murphy*. Identification and Quantification of Protein S-nitrosation by Nitrite in the Mouse Heart during Ischemia. Journal of Biological Chemistry 4. Lawrence Kazak, Edward T Chouchani, Irina G Stavrovskaya, Gina Z Lu, Mark P Jedrychowski, Daniel F Egan, Manju Kumari, Xingxing Kong, Brian K Erickson, John Szpyt, Evan D Rosen, Michael P Murphy, Bruce S Kristal, Steven P Gygi, Bruce M Spiegelman. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. PNAS 5. Ambre M Bertholet, Lawrence Kazak, Edward T Chouchani, Marta G Bogaczyńska, Ishan Paranjpe, Gabrielle L Wainwright, Alexandre Bétourné, Shingo Kajimura, Bruce M Spiegelman, Yuriy Kirichok. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metabolism 6. Sara P Ortega, Edward T Chouchani, Sihem Boudina. Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes. Adipocyte |
|
2016 AND PRIOR
|
1. Victoria R Pell, Edward T Chouchani, Christian Frezza, Michael P Murphy, Thomas Krieg.
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury. Cardiovascular Research 2. Edward T Chouchani, Lawrence Kazak, Mark P Jedrychowski, Gina Z Lu, Brian K Erickson, John Szpyt, Kerry A Pierce, Dina Laznik-Bogoslavski, Ramalingam Vetrivelan, Clary B Clish, Alan J Robinson, Steve P Gygi, Bruce M Spiegelman. Mitochondrial ROS control thermogenic energy expenditure and sulfenylation of UCP1. Nature 3. Victoria R Pell, Edward T Chouchani, Michael P Murphy, Paul S Brookes, Thomas Krieg. Moving forwards by blocking back-flow: the yin and yang of MI therapy. Circulation Research 4. Edward T Chouchani, Victoria R Pell, Andrew M James, Lorraine M Work, Kourosh Saeb-Parsy, Christian Frezza, Thomas Krieg, Michael P Murphy. A Unifying Mechanism for Mitochondrial Superoxide Production During Ischemia-Reperfusion Injury. Cell Metabolism 5. Angela Logan, Victoria R. Pell, Karl J. Shaffer, Cameron Evans, Nathan J. Stanley, Ellen L. Robb, Tracy A. Prime, Edward T. Chouchani, Helena M. Cochemé, Ian M. Fearnley, Sara Vidoni, Andrew M. James, Carolyn M. Porteous, Linda Partridge, Thomas Krieg, Robin A. J. Smith, Michael P. Murphy. Assessing the Mitochondrial Membrane Potential in Cells and In Vivo Using Targeted Click Chemistry and Mass Spectrometry. Cell Metabolism 6. Lawrence Kazak, Edward T. Chouchani, Mark P. Jedrychowski, Brian K. Erickson, Kosaku Shinoda, Paul Cohen, Ramalingam Vetrivelan, Gina Z. Lu, Dina Laznik-Bogoslavski, Sebastian Hasenfuss, Shingo Kajimura, Steve P. Gygi, Bruce M. Spiegelman. A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat. Cell 7. Katja E Menger, Andrew M. James, Helena M Cochemé, Michael Harbour, Edward T. Chouchani, Shujing Ding, Ian M Fearnley , Linda Partridge, Michael P Murphy. Fasting but not Ageing Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster. Cell Reports 8. Brian Cunniff, Kheng Newick, Kimberly J Nelson, Alexandra N. Wozniak, Stacie Beuschel, Bruce Leavitt, Anant Bhave, Kelly Butnor, Andreas Koenig, Edward T. Chouchani, Andrew M. James, Alexina C. Haynes, W. Todd Lowther, Michael P. Murphy, Arti Shukla, Nicholas H. Heintz. Disabling mitochondrial peroxide metabolism via combinatorial targeting of peroxiredoxin 3 as effective therapeutic approach for malignant mesothelioma. PLoS One 9. Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Sundier, Ellen L. Robb, Angela Logan, Sergiy M. Nadtochiy, Anthony C. Smith, Filmon Eyassu, Emily N. J. Ord, Rachel Shirley, Chou-Hui Hu, Anna J. Dare, Andrew M. James, Sebastian Rogatti, Simon Eaton, Paul S. Brookes, Sean M. Davidson, Michael R. Duchen, Kourosh Saeb-Parsy, Michael J. Shattock, Alan J. Robinson, Lorraine M. Work, Christian Frezza, Thomas Krieg, Michael P. Murphy. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 10. Carmen Methner, Edward T. Chouchani, Guido Buonincontri, Stephen J. Sawiak, Michael P. Murphy, Thomas Krieg. Mitochondria selective S-nitrosation by MitoSNO protects against post-infarct heart failure in mouse hearts. Eur J Heart Fail 11. Edward T. Chouchani, Chou-Hui Hu, Guido Buonincontri, Carmen Methner, Angela Logan, Chou-Hui Hu, Stephen J. Sawiak, Michael P. Murphy, and Thomas Krieg. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. PLoS One 12. Angela Logan, Helena M. Cochemé, Pamela Boon Li Pun, Nadezda Apostolova, Robin A. J. Smith, Lesley Larsen, David S. Larsen, Andrew M. James, Ian M. Fearnley, Sebastian Rogatti, Tracy A. Prime, Peter Finichiu, Anna Dare, Edward T. Chouchani, Victoria R. Pell, Carmen Methner, Caroline Quin, Stephen J. McQuaker, Thomas Krieg, Richard C. Hartley, Michael P. Murphy. Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica Biophysica Acta 13. Edward T. Chouchani, Carmen Methner, Sergiy M. Nadtochiy, Angela Logan, Victoria R. Pell, Shujing Ding, Andrew M. James, Helena M. Cochemé, Johannes Reinhold, Kathryn S. Lilley, Linda Partridge, Ian M. Fearnley, Alan J. Robinson, Richard C. Hartley, Robin A.J. Smith, Thomas Krieg, Paul S. Brookes, Michael P. Murphy. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine 14. Thomas R. Hurd, Yvonne Collins, Irina Abakamova, Edward T. Chouchani, Bartlomiej Baranowski, Ian M. Fearnley, Tracy A. Prime, Michael P. Murphy, Andrew M. James. Redox regulation of pyruvate dehydrogenase by cysteine oxidation on pyruvate dehydrogenase kinase 2. Journal of Biological Chemistry 15. Yvonne Collins, Edward T. Chouchani, Andrew M. James, Katja E. Menger, Helena M. Cocheme, Michael P. Murphy. Mitochondrial redox signaling at a glance. Journal of Cell Science 16. Edward T. Chouchani, Andrew M. James, Ian M. Fearnley, Kathryn S. Lilley, Michael P. Murphy. Proteomic approaches to the characterization of protein thiol modification. Current Opinion in Chemical Biology 17. Raquel Requejo, Edward T. Chouchani, Andrew M. James, Tracy A. Prime, Kathryn S. Lilley, Ian M. Fearnley, and Michael P. Murphy. Quantification and identification of mitochondrial proteins containing vicinal dithiols. Archives of Biochemistry and Biophysics 18. Raquel Requejo, Edward T. Chouchani, Thomas R. Hurd, Katja E. Menger, Mark B. Hampton, Michael P. Murphy. Measuring Mitochondrial Protein Thiol Redox State. Methods in Enzymology 19. Edward T. Chouchani, Thomas R. Hurd, Sergiy M. Nadtochiy, Paul S. Brookes, Ian M. Fearnley, Kathryn S. Lilley, Robin A.J. Smith, Michael P. Murphy. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): Implications for the regulation of mitochondrial function by reversible S-nitrosation. Biochemical Journal 20. Tracy A. Prime, Francis H. Blaikie, Chris Evans, Sergiy M. Nadtochiy, Andrew M. James, Christina Dahm, Dario A. Vitturi, Rakesh P. Patel, C. Robin Hiley, Irina Abakumova, Raquel Requejo, Edward T. Chouchani, Thomas R. Hurd, John F. Garvey, Cormac T. Taylor, Paul S. Brookes, Robin A.J. Smith, Michael P. Murphy. A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. PNAS |