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2019
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1. P. Kent Langston, Aya Nambu, Jonathan Jung, Munehiko Shibata, H. Ibrahim Aksoylar, Jiahui Lei, Peining Xu, Mary T. Doan, Helen Jiang, Michael R. MacArthur, Xia Gao, Yong Kong, Edward T. Chouchani, Jason W. Locasale, Nathaniel W. Synder & Tiffany Horng. Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.
Nature Immunology 2. Ambre M. Bertholet, Edward T. Chouchani, Lawrence Kazak, Alessia Angelin, Andriy Fedorenko, Jonathan Z. Long, Sara Vidoni, Ryan Garrity, Joonseok Cho, Naohiro Terada, Douglas C. Wallace, Bruce M. Spiegelman & Yuriy Kirichok. H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature 3. Lawrence Kazak, Janane F Rahbani, Bozena Samborska, Gina Z Lu, Mark P Jedrychowski, Mathieu Lajoie, Song Zhang, LeeAnn Ramsay, Florence Y Dou, Danielle Tenen, Edward T Chouchani , Petras Dzeja, Ian R Watson, Linus Tsai, Evan D Rosen & Bruce M Spiegelman. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nature Metabolism 4. Edward T. Chouchani# & Shingo Kajimura. Metabolic adaptation and maladaptation in adipose tissue. Nature Metabolism |
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2018
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1. Edward T. Chouchani#, Lawrence Kazak# & Bruce M. Spiegelman#. New Advances in Adaptive Thermogenesis: UCP1 and Beyond.
Cell Metabolism 2. Evanna L. Mills, Kerry A. Pierce, Mark P. Jedrychowski, Ryan Garrity, Sally Winther, Sara Vidoni, Takeshi Yoneshiro, Jessica B. Spinelli, Gina Z. Lu, Lawrence Kazak, Alexander S. Banks, Marcia C. Haigis, Shingo Kajimura, Michael P. Murphy, Steven P. Gygi, Clary B. Clish & Edward T. Chouchani#. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature 3. Joao A. Paulo, Mark P. Jedrychowski, Edward T. Chouchani, Lawrence Kazak & Steven P. Gygi. Multiplexed Isobaric Tag-Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy. Proteomics 4. Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Roman Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark M. Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L. J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova-Kostova, Richard C. Hartley, Michael P. Murphy & Luke A. O’Neill. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 Nature |
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2017
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1. Edward T Chouchani, Lawrence Kazak and Bruce M Spiegelman. Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms.
Journal of Biological Chemistry 2. Lawrence Kazak, Edward T. Chouchani, Gina Z. Lu, Mark P. Jedrychowski, Curtis J. Bare, Amir I. Mina, Manju Kumari, Song Zhang, Ivan Vuckovic, Dina Laznik-Bogoslavski, Petras Dzeja, Alexander S. Banks, Evan D. Rosen, Bruce M. Spiegelman. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metabolism 3. Edward T Chouchani#, Andrew M James#, Carmen Methner, Victoria R Pell, Tracy A Prime, Brian K Erikson, Marleen Forkink, Gigi Y Lau, Thomas P Bright, Katja E Menger, Ian M Fearnley, Thomas Krieg, Michael P Murphy#. Identification and Quantification of Protein S-nitrosation by Nitrite in the Mouse Heart during Ischemia. Journal of Biological Chemistry # - Corresponding Authors 4. Lawrence Kazak, Edward T Chouchani, Irina G Stavrovskaya, Gina Z Lu, Mark P Jedrychowski, Daniel F Egan, Manju Kumari, Xingxing Kong, Brian K Erickson, John Szpyt, Evan D Rosen, Michael P Murphy, Bruce S Kristal, Steven P Gygi, Bruce M Spiegelman. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. PNAS 5. Ambre M Bertholet, Lawrence Kazak, Edward T. Chouchani, Marta G .Bogaczyńska, Ishan Paranjpe, Gabrielle L Wainwright, Alexandre Bétourné, Shingo Kajimura, Bruce M. Spiegelman, Yuriy Kirichok. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metabolism 6. Sara P. Ortega, Edward T. Chouchani, Sihem Boudina. Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes. Adipocyte |
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2016
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1. Victoria R. Pell, Edward T. Chouchani, Christian Frezza, Michael P. Murphy, Thomas Krieg. Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Cardiovascular Research 2. Edward T. Chouchani, Lawrence Kazak, Mark P. Jedrychowski, Gina Z. Lu, Brian K. Erickson, John Szpyt, Kerry A. Pierce, Dina Laznik-Bogoslavski, Ramalingam Vetrivelan, Clary B. Clish, Alan J. Robinson, Steve P. Gygi, and Bruce M. Spiegelman. Mitochondrial ROS control thermogenic energy expenditure and sulfenylation of UCP1. Nature 3. Victoria R. Pell, Edward T. Chouchani, Michael P. Murphy, Paul S. Brookes, Thomas Krieg. Moving forwards by blocking back-flow: the yin and yang of MI therapy. Circulation Research 4. Edward T. Chouchani, Victoria R. Pell, Andrew M. James, Lorraine M. Work, Kourosh Saeb-Parsy, Christian Frezza, Thomas Krieg, and Michael P. Murphy. A Unifying Mechanism for Mitochondrial Superoxide Production During Ischemia-Reperfusion Injury. Cell Metabolism |
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2015
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1. Angela Logan, Victoria R. Pell, Karl J. Shaffer, Cameron Evans, Nathan J. Stanley, Ellen L. Robb, Tracy A. Prime, Edward T. Chouchani, Helena M. Cochemé, Ian M. Fearnley, Sara Vidoni, Andrew M. James, Carolyn M. Porteous, Linda Partridge, Thomas Krieg, Robin A. J. Smith, and Michael P. Murphy. Assessing the Mitochondrial Membrane Potential in Cells and In Vivo Using Targeted Click Chemistry and Mass Spectrometry.
Cell Metabolism 2. Lawrence Kazak, Edward T. Chouchani, Mark P. Jedrychowski, Brian K. Erickson, Kosaku Shinoda, Paul Cohen, Ramalingam Vetrivelan, Gina Z. Lu, Dina Laznik-Bogoslavski, Sebastian Hasenfuss, Shingo Kajimura, Steve P. Gygi, and Bruce M. Spiegelman. A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat. Cell 3. Katja E Menger, Andrew M. James, Helena M Cochemé, Michael Harbour, Edward T. Chouchani, Shujing Ding, Ian M Fearnley , Linda Partridge, and Michael P Murphy. Fasting but not Ageing Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster. Cell Reports 4. Brian Cunniff, Kheng Newick, Kimberly J Nelson, Alexandra N. Wozniak, Stacie Beuschel, Bruce Leavitt, Anant Bhave, Kelly Butnor, Andreas Koenig, Edward T. Chouchani, Andrew M. James, Alexina C. Haynes, W. Todd Lowther, Michael P. Murphy, Arti Shukla, Nicholas H. Heintz. Disabling mitochondrial peroxide metabolism via combinatorial targeting of peroxiredoxin 3 as effective therapeutic approach for malignant mesothelioma. PLoS One |
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2014 AND PRIOR
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1. Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Sundier, Ellen L. Robb, Angela Logan, Sergiy M. Nadtochiy, Anthony C. Smith, Filmon Eyassu, Emily N. J. Ord, Rachel Shirley, Chou-Hui Hu, Anna J. Dare, Andrew M. James, Sebastian Rogatti, Simon Eaton, Paul S. Brookes, Sean M. Davidson, Michael R. Duchen, Kourosh Saeb-Parsy, Michael J. Shattock, Alan J. Robinson, Lorraine M. Work, Christian Frezza, Thomas Krieg & Michael P. Murphy. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Nature 2. Carmen Methner, Edward T. Chouchani, Guido Buonincontri, Stephen J. Sawiak, Michael P. Murphy, Thomas Krieg. Mitochondria selective S-nitrosation by MitoSNO protects against post-infarct heart failure in mouse hearts. Eur J Heart Fail 3. Edward T. Chouchani, Chou-Hui Hu, Guido Buonincontri, Carmen Methner, Angela Logan, Chou-Hui Hu, Stephen J. Sawiak, Michael P. Murphy, and Thomas Krieg. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. PLoS One 4. Angela Logan, Helena M. Cochemé, Pamela Boon Li Pun, Nadezda Apostolova, Robin A. J. Smith, Lesley Larsen, David S. Larsen, Andrew M. James, Ian M. Fearnley, Sebastian Rogatti, Tracy A. Prime, Peter Finichiu, Anna Dare, Edward T. Chouchani, Victoria R. Pell, Carmen Methner, Caroline Quin, Stephen J. McQuaker, Thomas Krieg, Richard C. Hartley, Michael P. Murphy. Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica Biophysica Acta 5. Edward T. Chouchani, Carmen Methner, Sergiy M. Nadtochiy, Angela Logan, Victoria R. Pell, Shujing Ding, Andrew M. James, Helena M. Cochemé, Johannes Reinhold, Kathryn S. Lilley, Linda Partridge, Ian M. Fearnley, Alan J. Robinson, Richard C. Hartley, Robin A.J. Smith, Thomas Krieg, Paul S. Brookes, and Michael P. Murphy. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine 6. Thomas R. Hurd, Yvonne Collins, Irina Abakamova, Edward T. Chouchani, Bartlomiej Baranowski, Ian M. Fearnley, Tracy A. Prime, Michael P. Murphy, and Andrew M. James. Redox regulation of pyruvate dehydrogenase by cysteine oxidation on pyruvate dehydrogenase kinase 2. Journal of Biological Chemistry 7. Yvonne Collins, Edward T. Chouchani, Andrew M. James, Katja E. Menger, Helena M. Cocheme, and Michael P. Murphy. Mitochondrial redox signaling at a glance. Journal of Cell Science 8. Edward T. Chouchani, Andrew M. James, Ian M. Fearnley, Kathryn S. Lilley, and Michael P. Murphy. Proteomic approaches to the characterization of protein thiol modification. Current Opinion in Chemical Biology 9. Raquel Requejo, Edward T. Chouchani, Andrew M. James, Tracy A. Prime, Kathryn S. Lilley, Ian M. Fearnley, and Michael P. Murphy. Quantification and identification of mitochondrial proteins containing vicinal dithiols. Archives of Biochemistry and Biophysics 10. Raquel Requejo, Edward T. Chouchani, Thomas R. Hurd, Katja E. Menger, Mark B. Hampton and Michael P. Murphy. Measuring Mitochondrial Protein Thiol Redox State. Methods in Enzymology 11. Edward T. Chouchani, Thomas R. Hurd, Sergiy M. Nadtochiy, Paul S. Brookes, Ian M. Fearnley, Kathryn S. Lilley, Robin A.J. Smith, Michael P. Murphy. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): Implications for the regulation of mitochondrial function by reversible S-nitrosation. Biochemical Journal 12. Tracy A. Prime, Francis H. Blaikie, Chris Evans, Sergiy M. Nadtochiy, Andrew M. James, Christina Dahm, Dario A. Vitturi, Rakesh P. Patel, C. Robin Hiley, Irina Abakumova, Raquel Requejo, Edward T. Chouchani, Thomas R. Hurd, John F. Garvey, Cormac T. Taylor, Paul S. Brookes, Robin A.J. Smith, Michael P. Murphy. A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. PNAS |