What we do
We apply mass spectrometry and biochemical approaches to understand how metabolites regulate cellular function in
pre-clinical models of health and disease.
Our goal is to leverage these newfound mechanisms to develop new therapies for metabolic, inflammatory, and metastatic diseases.
June 2023 - Ed was awarded the Bodossaki Distinguished Young Scientist Award. Congratulations!
March 2023 - Our paper on the discovery of a biochemical mechanism for lactate control over protein function is out in Nature!
February 2023 - Our paper on a first in class covalent inhibitor for Creatine Kinases is out in Nature Chemical Biology!
November 2022 - Our OPABAT paper on using outbred proteomics to identify metabolic regulators is out in Cell!
October 2022 - Ed was awarded with a 2023 Vilcek Prize for Creative Promise. Congratulations!
October 2022 - Matchpoint Therapeutics launches, with Ed as Scientific Co-Founder, based on science developed in the Chouchani Lab.
May 2022 - Mei Ying successfully defended her PhD thesis. Congratulations Dr. Ng!
May 2022 - Haopeng, Luiz, and Nils all received fellowships (K99, AHA, DFG). Congratulations!
April 2022 - Our paper, "Why Succinate?" is out in Nature Chemical Biology!
March 2022 - Evanna has started her own lab as an Assistant Professor at DFCI/HMS. Congratulations!
December 2021 - Our paper on physiological regulation of metabolic tissue inflammation by UCP1 cysteine 253 is out in Cell Metabolism!
July 2021 - Martha was named a 2021 HHMI Gilliam Fellow. Congratulations!
June 2021 - Ed was named a 2021 Pew Scholar. Congratulations!
May 2021 - Our paper on a newfound role for adipose tissue-regulated succinate in liver pathology is out in Nature Metabolism!
May 2021 - Ed was awarded the 2021 Helmholtz Young Investigator in Diabetes (HeIDi) Award. Congratulations!
May 2021 - Ed was awarded the 2021 Armen H. Tashjian Award for Excellence in Endocrine Research. Congratulations!
January 2021 - Anita was awarded a F31 fellowship. Congratulations Anita!
September 2020 - Our paper on pH-gated succinate release regulating muscle adaptation to exercise it out in Cell. Congrats all!
August 2020 - Evanna was awarded a K99 post-doctoral fellowship to study mechanisms of regulation of systemic inflammation by brown adipose tissue and succinate. Congratulations!
July 2020 - Nhien Tran joins us from the NIH as our new lab manager. Welcome!
February 2020 - Our Oximouse paper is out in Cell with a Perspective in Cell Metabolism. The online resource accompanying the paper can be found here. Congrats all!
October 2019 - Narek was awarded a T32 post-doctoral fellowship. Congratulations Narek!
August 2019 - Narek and Martha join the lab, just in time for cysteine proteomics bootcamp.
June 2019 - Haopeng was awarded a post-doctoral fellowship from the National Cancer Center. Congratulations Haopeng!
May 2019 - Mei Ying Ng joins us as a PhD student from NUS, welcome!
February 2019 - Eddie Nesmith joins us from the MCB program at Harvard, welcome!
January 2019 - Our review on metabolic adaptation and maladaptation in adipose tissue is out in Nature Metabolism.
November 2018 - Our review on mechanisms of adipose tissue thermogenesis is out in Cell Metabolism!
July 2018 - Our paper on the role of succinate in adipose tissue thermogenesis is out in Nature with a News & Views by Joshua Rabinowitz!
June 2018 - Haopeng joins us from GA Tech to develop new MS methods.
April 2018 - Our collaboration on itaconate was just published in Nature!
March 2018 - Sally was awarded a Novo Nordisk postdoctoral fellowship. Congratulations Sally!
March 2018 - Anita joined the lab as our first BBS PhD student, welcome!
January 2018 - Ed is giving a talk at the Keystone meeting on bioenergetics and metabolic disease
November 2017 - Weihai joined that lab as our first PhD student, welcome!