What we do
Our research focuses on deciphering the molecular mechanisms of metabolic disease and dysfunction, and using this information to develop targeted therapeutic strategies.
As we age the form and function of our cells is diminished, leading to decreased quality of life and increased risk of death. Dysfunction in a particular cellular locale – the mitochondrion – is implicated in much of this pathology.
We apply mass spectrometry and biochemical approaches to identify mitochondrial metabolic pathways that control the protective and pathological cascades initiated by this organelle.
Our work to date has focused on elucidating these mechanisms of damage and protection in pre-clinical models of cardiovascular and metabolic disease.
August 2019 - Narek and Martha join the lab, just in time for cysteine proteomics bootcamp!
June 2019 - Haopeng was awarded a post-doctoral fellowship from the National Cancer Center. Congratulations Haopeng!
May 2019 - Mei Ying Ng joins us as a PhD student from NUS, welcome!
February 2019 - Eddie Nesmith joins us from the MCB program at Harvard, welcome!
January 2019 - Our review on metabolic adaptation and maladaptation in adipose tissue is out in Nature Metabolism.
November 2018 - Our review on mechanisms of adipose tissue thermogenesis is out in Cell Metabolism!
July 2018 - Our paper on the role of succinate in adipose tissue thermogenesis is out in Nature with a News & Views by Joshua Rabinowitz!
July 2018 - Evanna gave a talk at the Redox Signaling GRC and was elected to chair their next GRS. Congrats!
June 2018 - Haopeng joins us from GA Tech to develop new MS methods.
April 2018 - Evanna's itaconate paper was just published in Nature!
March 2018 - Sally was awarded a Novo Nordisk postdoctoral fellowship. Congratulations Sally!
March 2018 - Anita joined the lab as our first BBS PhD student, welcome!
January 2018 - Ed is giving a talk at the Keystone meeting on bioenergetics and metabolic disease
November 2017 - Weihai joined that lab as our first PhD student, welcome!
May 2017 - Evanna was awarded an EMBO long-term fellowship. Congratulations Evanna!