CHOUCHANI LAB
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Metabolite regulation over health and disease
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What we do
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We apply mass spectrometry and biochemical approaches to understand how metabolites regulate cellular function in
pre-clinical models of health and disease.

Our goal is to leverage these newfound mechanisms to develop new therapies for metabolic, inflammatory, and metastatic diseases.
November 2022 - Our OPABAT paper on using outbred proteomics to identify metabolic regulators is out in Cell!

October 2022 -
Ed was awarded with a 2023 Vilcek Prize for Creative Promise. Congratulations! 

October 2022 - Matchpoint Therapeutics launches, with Ed as Scientific Co-Founder, based on science developed in the Chouchani Lab.

May 2022 - Mei Ying successfully defended her PhD thesis. Congratulations Dr. Ng!

May 2022 - Haopeng, Luiz, and Nils all received fellowships (K99, AHA, DFG).  Congratulations!


April 2022 - Our paper, "Why Succinate?" is out in Nature Chemical Biology!

March 2022 - Evanna has started her own lab as an Assistant Professor at DFCI/HMS.  Congratulations!

December 2021 - Our paper on physiological regulation of metabolic tissue inflammation by UCP1 cysteine 253 is out in Cell Metabolism!

July 2021 - Martha was named a 2021 HHMI Gilliam Fellow. Congratulations!


June 2021 - Ed was named a 2021 Pew Scholar.  Congratulations!

May 2021 - Our paper on a newfound role for adipose tissue-regulated succinate in liver pathology is out in Nature Metabolism!

May 2021 - Ed was awarded the 2021 
Helmholtz Young Investigator in Diabetes (HeIDi) Award. Congratulations!

May 2021 - Ed was awarded the 2021 Armen H. Tashjian Award for Excellence in Endocrine Research. Congratulations! 

January 2021
- Anita was awarded a F31 fellowship.  Congratulations Anita!

September 2020 - Our paper on pH-gated succinate release regulating muscle adaptation to exercise it out in Cell.  Congrats all!

August 2020 - Evanna was awarded a K99 post-doctoral fellowship to study mechanisms of regulation of systemic inflammation by brown adipose tissue and succinate. Congratulations!

July 2020 - Nhien Tran joins us from the NIH as our new lab manager. Welcome!

February 2020 - Our Oximouse paper is out in Cell with a Perspective in Cell Metabolism.  The online resource accompanying the paper can be found here. Congrats all! 

October 2019 - Narek was awarded a T32 post-doctoral fellowship. Congratulations Narek!

August 2019 - Narek and Martha join the lab, just in time for cysteine proteomics bootcamp.

June 2019 - Haopeng was awarded a post-doctoral fellowship from the National Cancer Center. Congratulations Haopeng!

May 2019 - Mei Ying Ng joins us as a PhD student from NUS, welcome!

February 2019 -  Eddie Nesmith joins us from the MCB program at Harvard, welcome!

​January 2019 - Our review on metabolic adaptation and maladaptation in adipose tissue is out in Nature Metabolism.

November 2018 - Our review on mechanisms of adipose tissue thermogenesis is out in Cell Metabolism!

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July 2018 - Our paper on the role of succinate in adipose tissue thermogenesis is out in Nature with a News & Views by Joshua Rabinowitz!

June 2018 - Haopeng joins us from GA Tech to develop new MS methods.

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April 2018 -  Our collaboration on itaconate was just published in Nature!
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​March 2018 - Sally was awarded a Novo Nordisk postdoctoral fellowship. Congratulations Sally!

March 2018 - Anita joined the lab as our first BBS PhD student, welcome!

January 2018 - Ed is giving a talk at the Keystone meeting on bioenergetics and metabolic disease

November 2017 - Weihai joined that lab as our first PhD student, welcome!

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©2017 Chouchani Lab at Dana-Farber Cancer Institute
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